I just found a little secret hidden in HoneyComb that allows you to create custom keyboard shortcuts on the ASUS EEE Pad Transformer which should work on the upcoming Transformer Prime keyboard and possibly on other hardware keyboards like bluetooth keyboards just as long as your Tablet (or Phone) is running on HoneyComb and ICS (and has a Search hardware button like the one in the Transformer Keyboard dock)
No rooting is required at all. Continue to read on the article which contains screenshots of this hidden "activity" that allows you to do something powerful in HoneyComb.